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Problem:

One column has letters in various sets (sometimes a-z, sometimes a-d; a-t; etc).

         

Solution

Notes:

  • Assume your data starts on column A, row 2  
  • IFERROR prevents #VALUE form showing in results, returns empty cell instead

lower case letters to numbers

=IFERROR(LOOKUP(A2,{"a","b","c","d","e","f","g","h","i","j","k","l","m","n","o","p","q","r","s","t","u","v","w","x","y","z"},{"1","2","3","4","5","6","7","8","9","10","11","12","13","14","15","16","17","18","19","20","21","22","23","24","25","26"}),"")

UPPER CASE LETTERS to numbers

=IFERROR(LOOKUP(A2,{"A","B","C","D","E","F","G","H","I","J","K","L","M","N","O","P","Q","R","S","T","U","V","W","X","Y","Z"},{"1","2","3","4","5","6","7","8","9","10","11","12","13","14","15","16","17","18","19","20","21","22","23","24","25","26"}),"")

numbers to lower case letters

=IFERROR(LOOKUP(A2,{1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26},{"a","b","c","d","e","f","g","h","i","j","k","l","m","n","o","p","q","r","s","t","u","v","w","x","y","z"}),"")

numbers to UPPER CASE LETTERS

=IFERROR(LOOKUP(A2,{1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26},{"A","B","C","D","E","F","G","H","I","J","K","L","M","N","O","P","Q","R","S","T","U","V","W","X","Y","Z"}),"")